Skip to content
Same day fulfillment on orders placed before 3 pm CST M-F.
Same day fulfillment on orders placed before 3 pm CST M-F.

SPM Active by Metagenics

SKU META1275
Original price $73.95 - Original price $124.95
Original price
$73.95
$73.95 - $124.95
Current price $73.95
Availability:
in stock, ready to be shipped
Availability:
in stock, ready to be shipped
UPC: 755571952295, 755571952301
Heat Sensitive Product: No
Manufacturer's Item Number: SPMA (60) | SPMA120 (120)
Amount: 60 | 120 Softgels
Restrictions:
Size: 60 Softgels

Delivery time

Most standard shipping orders arrive in 1-4 business days.
2 Day Shipping
Fast Free Shipping - Orders over $30
? Orders ship the same day if ordered before 3:00pm CST and most orders arrive in 2-4 business days. Shipping times are not guaranteed.

SPM Active by Metagenics harnesses the power of specialized pro-resolving mediators (SPMs)—naturally occurring molecules that help your body complete its inflammatory response cycle and return to a healthy, balanced state. This advanced formula supports your body's innate ability to recover from physical challenges and maintain optimal wellness.

Key Benefits of SPM Active:

  • Promotes Natural Resolution: Helps your body complete the inflammatory response cycle, supporting faster recovery from physical stress and exercise
  • Supports Healthy Tissue Function: Aids your body's natural repair processes to maintain tissue health and comfort
  • Enhances Immune Balance: Supports healthy immune cell activity and resolution-related functions for optimal immune system performance
  • Accelerates Recovery: May help reduce recovery time after physical challenges, keeping you active and feeling your best
  • Clinically-Researched Formula: Based on cutting-edge science around specialized pro-resolving mediators and their role in health

Why SPM Active Stands Out:

Unlike traditional approaches that simply address inflammation, SPM Active works with your body's natural resolution pathways. SPMs are the molecules your body produces to actively resolve inflammation and restore balance—this formula provides concentrated support for this critical process.

Perfect for active individuals, those recovering from physical challenges, or anyone looking to support their body's natural healing and recovery processes.

Quality You Can Trust:

  • Premium Marine Lipid Concentrate: Derived from sustainably sourced fish oil rich in bioactive SPMs
  • Metagenics Quality: Manufactured by a trusted leader in clinical nutrition with rigorous quality standards
  • Clean Formula: Non-GMO and gluten-free to meet your dietary needs
  • Science-Backed: Formulated based on the latest research in resolution physiology

Who Should Consider SPM Active?

This advanced formula is ideal for individuals who want to support their body's natural recovery processes, maintain healthy tissue function, and promote balanced immune responses. Whether you're an athlete, dealing with physical stress, or simply committed to proactive wellness, SPM Active provides targeted nutritional support.

Frequently Asked Questions

Is SPM Active the same as a standard Fish Oil or Omega-3?

While derived from high-quality marine lipids, SPM Active is not a standard fish oil. Traditional fish oils provide EPA and DHA, which are the precursors to resolving inflammation. SPM Active provides the Specialized Pro-Resolving Mediators themselves, which are the specific molecules your body uses to actually "switch off" the inflammatory response.

How many softgels should I take daily?

For general health maintenance, the standard serving is two softgels once daily. However, during periods of acute physical stress or recovery, a healthcare practitioner may recommend a higher loading dose to support the body’s natural resolution pathways.

Can I take SPM Active with other supplements?

Yes. SPM Active is often paired with Omega-3 concentrates or Curcumin for comprehensive joint and tissue support. Because it works on a different biological pathway (resolution vs. inhibition), it is considered a non-interfering "cleanup crew" for your cellular health.

Is this product Gluten-Free and Non-GMO?

Yes. Metagenics SPM Active is strictly Non-GMO, Gluten-Free, and Dairy-Free. It is manufactured in a triple-certified facility to ensure it is free from heavy metals and environmental contaminants.

How long does it take to feel the benefits of SPMs?

Many users notice a difference in tissue comfort and physical recovery within 3 to 5 days of consistent use, especially when recovering from intense physical exertion. For chronic support, optimal results are typically seen after 2–4 weeks.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Suggested Use: Take 2 softgels daily, or as directed by your health care practitioner.

Supplement Facts:
Serving Size: 2 softgels
Servings Per Container: 30

Amount Per Serving:
Calories 10
Total Fat 1 g
Cholesterol <5 mg
Active Fractionated Marine Lipid Concentrate 1 g
SPM content standardized to
18-hydroxy-eicosapentaenoic acid (18-HEPE)
17-hydroxy-docosahexaenoic acid (17-HDHA)
14-hydroxy-docosahexaenoic acid (14-HDHA)

Other Ingredients:
Fractionated marine lipid concentrate [fish oil (anchovy, sardine, andmackerel) and mixed tocopherols (antioxidant)], softgel shell (gelatin, glycerin,and water), and silica.

*Contains: Fish (anchovy, sardine, and mackerel).

Warnings:
If pregnant, nursing, or taking nutritional supplements or medications, consult your healthcare practitioner before use. Keep out of the reach of children.

Storage:
Store in a cool, dry place.

**These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Overall rating: 4.40625 / 5 from 32 reviews.

AI Generated Review Summary

SPM Active by Metagenics supports the body's natural recovery process, helping to complete the inflammatory response cycle and maintain optimal wellness. It aids in faster recovery from physical stress, supports healthy tissue function, and enhances immune balance. Ideal for active individuals and those recovering from physical challenges.

Summary topics

  • Pain Relief: 27%
  • Supplement Quality: 20%

Review topics: ["pain","results","formula","service","body","difference","works","supplement","doctor","spm active","knees","fish oil"].

Review highlights

  • "Metagenic is my favorite supplement."Anonymous
  • "Quick delivery and a great product."Susan R.
  • "These little capsules seem to really help my arthritic knees."DANA

Reviews

SPM Active really helps to

"SPM Active really helps to relieve inflammation in my body. Upon taking this supplement for only a short while, my pain has decreased significantly and I recover quickly from injuries due to muscle overuse. I was so pleased to find this product that does so much good for my body."

Carol M. (5/5)

Metagenics

"My Nutritionist recommended I add these into my morning repertoire and the results are everything he said they would be. I have energy and my whole body is functioning at a higher level. I can’t describe how grateful I am for this amazing feeling of living life at its best. I was even able to take a trip. . . the first time in a year that I could actually be away from home!"

Kathy H. (1/5)

Recommended

"It was recommended by the nutritionist that I use. However, I recently bought a bottle as I read the price, which was high-ish, was going to escalate. I will need to check with the practicitoner to see whether something can be substituted."

Marcia W. (5/5)

Amazing

"This stuff is amazing. I helped clear up my acne scars, it helps my inflammation go down and my constipation ease!"

Madelyn H. (5/5)

Recommended by my doctor

"My doctor recommended this product. I've taken it for about 2 months and my overall aches and pains are much better. I will continue taking this for the foreseeable future."

Nancy H. (5/5)

Simply amazing

"SPM active was recommended to me by a sports doctor after he refused to give me a cortisol shot in my shoulder. I bought some and low and behold, it worked. I have not had shoulder pain since. My wife was suffering from inflammation in her lungs and was on oxygen and couldn't take steroids for it. I suggested she try some of my SPM Active and it worked better than any of the drugs she'd been prescribed. It's simply an amazing product for fighting inflammation."

James C. (5/5)

potent and effective formula

"This is truly helping manage and reduce inflammation which I have due to osteoarthritis."

Ursula H. (5/5)

Haven't noticed a difference

"I have heard this works well, and trust it is working internally the way it should! I just have not felt or seen a noticeable difference."

Elise L. (4/5)

Great supplement

"Helps support immune response, especially during challenging times. It is non-GMO and gluten free. Helps reduce inflammation which helps reduce pain."

S. T. (5/5)

Amazing

"SPM Active was recommended by my integrative specialist when I developed inflammatory issues after being injured by an antibiotic. I have been taking it for 3 years now. My chronic pain is minimal to not noticeable and my Raynaud’s blue fingers don’t appear any more. Things were a little better when I changed my food protocol, but adding SPMActive was definitely a game changer."

Brenda N. (5/5)

Q&A

Can you take spm active with glucosamine?
Yes, you can take SPM Active by Metagenics alongside glucosamine. There are no direct contraindications listed between these two supplements

Compare products

{"one"=>"Select 2 or 3 items to compare", "other"=>"{{ count }} of 3 items selected"}

Select first item to compare

Select second item to compare

Select third item to compare

Compare