Sleep Relief 60 Tablets by NBI

Sleep Relief by NBI is a professional-grade sleep support formula designed to promote healthy sleep onset, support normal sleep duration and quality, and maintain healthy circadian rhythm regulation. This 60-tablet formula combines melatonin with evidence-informed botanical sedatives, calming amino acids, and GABA-supportive nutrients to address multiple neurological pathways involved in healthy sleep architecture.

Key Benefits of Sleep-Supporting, Calming, and Circadian Rhythm Nutrients

• Melatonin: The primary circadian rhythm hormone that supports healthy sleep onset, promotes normal sleep-wake cycle regulation, and maintains healthy pineal gland signaling in response to light-dark cycles. Included at a clinically relevant dose to support normal sleep latency without excessive sedation.
• L-Theanine: An amino acid found naturally in green tea that promotes a calm, relaxed mental state without sedation, supporting healthy alpha brain wave activity and normal transition from wakefulness to sleep.
• GABA (Gamma-Aminobutyric Acid): The primary inhibitory neurotransmitter in the central nervous system, supporting healthy neuronal calming activity and promoting a normal relaxation response in preparation for sleep.
• Valerian Root (Valeriana officinalis) Extract: A well-studied botanical that supports healthy GABA-A receptor activity, promotes normal sleep onset, and maintains healthy sleep quality and duration through its valerenic acid content.
• Passionflower (Passiflora incarnata) Aerial Parts Extract: Supports healthy GABA activity and promotes a normal calming response in the central nervous system, maintaining healthy sleep quality and reducing the impact of occasional restlessness on sleep onset.
• Lemon Balm (Melissa officinalis) Leaf Extract: Supports healthy GABA transaminase activity, promoting normal GABA availability in the brain and maintaining a calm, relaxed state conducive to healthy sleep onset.
• Hops (Humulus lupulus) Strobiles Extract: Supports healthy sedative activity through its interaction with GABA-A receptors and promotes normal sleep onset and duration, particularly when combined with Valerian Root.
• Magnesium (as Magnesium Glycinate): Supports healthy GABA receptor function, promotes normal muscle relaxation, and maintains healthy melatonin synthesis as a cofactor for the enzymes involved in melatonin production from serotonin.
• 5-HTP (5-Hydroxytryptophan, from Griffonia simplicifolia): A direct precursor to serotonin and subsequently melatonin, supporting healthy neurotransmitter synthesis and promoting normal sleep architecture, mood balance, and circadian rhythm regulation.
• Vitamin B6 (as Pyridoxal-5-Phosphate): An essential cofactor for the conversion of 5-HTP to serotonin and tryptophan to serotonin, supporting healthy neurotransmitter synthesis and promoting normal melatonin production.
• Ashwagandha (Withania somnifera) Root Extract (KSM-66): Supports healthy cortisol balance and promotes normal stress adaptation, maintaining a calm physiological state that supports healthy sleep onset and quality in individuals experiencing occasional stress-related sleep disruption.
• Glycine: An inhibitory amino acid and neurotransmitter that supports healthy core body temperature reduction associated with normal sleep onset and promotes normal REM sleep architecture and sleep quality.

Why This Formula Matters

Sleep Relief is formulated around a multi-pathway approach to sleep support that addresses the three primary neurological dimensions of healthy sleep: circadian rhythm signaling through melatonin, GABAergic calming activity through Valerian, Passionflower, Lemon Balm, and Hops, and neurotransmitter precursor support through 5-HTP, Vitamin B6, and Magnesium. By combining melatonin with botanical GABA modulators and serotonin precursors rather than relying on melatonin alone, this formula supports both the timing and the quality of sleep, addressing the neurochemical environment that determines how deeply and restoratively the body sleeps. The inclusion of KSM-66 Ashwagandha and L-Theanine further supports the cortisol and stress adaptation dimension of sleep disruption, making this formula relevant for individuals whose sleep challenges are related to occasional stress and mental restlessness as well as circadian timing.

Dietary & Quality Standards

• Free from wheat, gluten, soy, milk, eggs, fish, crustacean shellfish, tree nuts, and peanuts
• Melatonin included at a clinically relevant dose for sleep onset support
• KSM-66 Ashwagandha standardized extract for consistent adaptogenic activity
• Active Vitamin B6 as Pyridoxal-5-Phosphate for enhanced neurotransmitter cofactor activity
• Manufactured by NBI under professional-grade quality standards
• Practitioner-formulated for clinical and integrative wellness use

Frequently Asked Questions

What is Sleep Relief used for?

Sleep Relief is a multi-ingredient sleep support formula designed to promote healthy sleep onset, support normal sleep duration and quality, and maintain healthy circadian rhythm regulation. It is intended for adults experiencing occasional difficulty falling or staying asleep, particularly those whose sleep challenges are related to stress, mental restlessness, or circadian disruption.

How do I take Sleep Relief?

The recommended use is as directed by a qualified healthcare practitioner. Sleep support formulas containing melatonin are generally taken 30 to 60 minutes before the desired sleep time. Consistent timing relative to your intended sleep schedule supports healthy circadian rhythm entrainment over time.

Does Sleep Relief cause morning grogginess?

This formula is designed to support healthy sleep onset and quality without excessive sedation. Melatonin at moderate doses and botanical GABA modulators such as Valerian and Passionflower are generally well tolerated without significant next-day sedation in most individuals. Response varies based on individual sensitivity, dose, and timing. If morning grogginess occurs, consult your healthcare provider about adjusting the dose or timing.

Is Sleep Relief habit-forming?

The ingredients in this formula, including melatonin, Valerian, Passionflower, and L-Theanine, are not considered habit-forming in the same manner as pharmaceutical sleep aids. However, long-term reliance on any sleep supplement without addressing underlying sleep hygiene factors is not recommended. Consult your healthcare provider if sleep difficulties persist beyond occasional use.

Can Sleep Relief be taken with other medications or supplements?

Some ingredients in this formula, including Valerian, Passionflower, and 5-HTP, may interact with sedative medications, antidepressants, or other serotonergic compounds. Individuals taking prescription sleep aids, antidepressants, anti-anxiety medications, or other CNS-active medications should consult their healthcare provider before using this product.

Is Sleep Relief safe for long-term use?

This formula is intended for occasional use to support healthy sleep onset and quality. For individuals with chronic sleep difficulties, a comprehensive evaluation by a qualified healthcare provider is recommended to identify and address underlying causes. Long-term use of melatonin and botanical sleep aids should be supervised by a healthcare practitioner.