PEA Soothe Topical Cream 3 oz by Neurobiologix delivers Palmitoylethanolamide (PEA) in a smooth, liposomal topical cream formulated with Boswellia, Myrrh, Jojoba Oil, Shea Butter, and Aloe Vera to support healthy inflammatory response, neuroprotection, and skin comfort directly at the site of application.
Key Benefits of PEA, Boswellia, Myrrh, Jojoba Oil, Shea Butter, and Aloe Vera Topical Ingredients
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Palmitoylethanolamide (PEA, 20mg per pump, 2% by weight)
- Supports healthy inflammatory response as a bio-identical fatty acid amide naturally synthesized by the body's own tissues, promoting neuroprotection, mast cell regulation, and homeostasis through topical delivery directly to affected areas
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Boswellia serrata (Indian Frankincense) Resin
- Supports healthy inflammatory response through AKBA (acetyl-11-keto-beta-boswellic acid) activity and promotes joint and tissue comfort through 5-LOX pathway modulation
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Commiphora myrrha (Myrrh)
- Promotes antioxidant and anti-inflammatory activity and supports healthy tissue response through terpenoid compounds with established use in topical wellness applications
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Liposomal Topical Delivery System
- Supports enhanced penetration of PEA and botanical actives through the skin barrier and promotes targeted delivery to underlying tissues at the site of application
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Simmondsia chinensis (Jojoba) Oil
- Supports skin barrier integrity and promotes a smooth, non-greasy application experience while facilitating absorption of active ingredients through its structural similarity to human sebum
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Vitellaria paradoxa (Shea) Butter
- Promotes skin hydration and supports a protective emollient barrier that maintains moisture and supports skin comfort at the application site
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Aloe Vera
- Supports skin soothing and promotes healthy tissue response at the application site through polysaccharide and acemannan compounds with established topical wellness activity
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Ascorbic Acid (Vitamin C)
- Supports antioxidant protection of the cream formulation and promotes skin health and collagen synthesis at the application site
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Stearyl Alcohol and Stearic Acid Base
- Supports a stable, smooth cream consistency and promotes even distribution of active ingredients across the skin surface
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Topical Application Convenience
- Pump dispenser delivers a consistent 1ml dose per pump, supporting precise and hygienic application up to 4 times daily
PEA Soothe Topical Cream provides a complementary delivery route to the oral PEA Soothe Support capsules, allowing PEA to be applied directly to specific areas of concern for localized support. The liposomal cream base is designed to support penetration of PEA through the skin barrier, which is a meaningful consideration given that PEA's primary activity occurs in peripheral tissues including mast cells, glia, and neurons near the site of application. The addition of Boswellia and Myrrh provides complementary botanical anti-inflammatory support through distinct molecular pathways, creating a multi-mechanism topical formula that addresses healthy inflammatory response from multiple angles simultaneously.
Dietary and Quality Standards
- Non-GMO
- Gluten-Free
- For external use only
- Liposomal topical delivery system
- 2% PEA concentration (20mg per pump)
- No artificial colors or preservatives
- Plant-derived botanical actives (Boswellia, Myrrh, Jojoba, Shea, Aloe)
- Store below 80 degrees F, do not freeze
- Manufactured in a GMP-certified facility
- Professional-grade formula
Frequently Asked Questions
Who is PEA Soothe Topical Cream designed for?
PEA Soothe Topical Cream is formulated for adults seeking localized support for healthy inflammatory response and tissue comfort at specific areas of the body. It is commonly used alongside the oral PEA Soothe Support capsules as part of a comprehensive PEA protocol, or as a standalone topical option for individuals who prefer targeted application. It is not intended for use during pregnancy or breastfeeding.
How should PEA Soothe Topical Cream be applied?
Apply the cream to the skin on the affected area up to 4 times per day, or as directed by a qualified healthcare professional. Each pump dispenses approximately 1ml of cream containing approximately 20mg of PEA. When opening a new bottle, a few pumps may be needed to prime the dispenser before product is dispensed. Store below 80 degrees F and do not freeze.
What is the advantage of topical PEA delivery compared to oral supplementation?
Topical application of PEA supports localized delivery directly to peripheral tissues at the site of application, including skin, underlying connective tissue, and peripheral nerve endings where mast cells and other PEA-responsive cells are concentrated. This targeted approach complements oral PEA supplementation, which supports systemic PEA levels throughout the body. Using both routes together may provide more comprehensive support for individuals with specific localized concerns alongside broader systemic inflammatory support needs.
Boswellia serrata, also known as Indian Frankincense, contains active compounds called boswellic acids, particularly AKBA, that support healthy inflammatory response by modulating the 5-lipoxygenase (5-LOX) enzyme pathway. This mechanism is distinct from PEA's PPAR-alpha activity, making Boswellia a complementary addition that addresses healthy inflammatory response through a different molecular pathway within the same topical application.
Can PEA Soothe Topical Cream be used alongside the oral PEA Soothe Support capsules?
Yes, the topical cream and oral capsules are designed to complement each other. The oral capsules support systemic PEA levels throughout the body, while the topical cream supports localized delivery to specific areas of concern. Using both together as part of a comprehensive protocol should be guided by a qualified healthcare practitioner based on individual health status and therapeutic goals.
Is this product safe for sensitive skin?
PEA Soothe Topical Cream is formulated with skin-supportive ingredients including Jojoba Oil, Shea Butter, and Aloe Vera, which are generally well-tolerated by most skin types. Individuals with known sensitivities to any of the listed botanical ingredients, including Boswellia, Myrrh, or Jojoba, should perform a patch test on a small area of skin before broader application and consult their healthcare provider if any reaction occurs.
Does this product contain any common allergens?
PEA Soothe Topical Cream is formulated to be Non-GMO and Gluten-Free. It contains no artificial colors or preservatives. Individuals with known sensitivities to tree nut-derived ingredients should note that Shea Butter is derived from the Shea tree. As with any topical product, review the full ingredient list and consult a healthcare provider if you have specific skin sensitivities or allergies.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
