PEA Soothe Support 90 Capsules by Neurobiologix is an enhanced formula delivering 350mg of Palmitoylethanolamide (PEA) per capsule alongside Resveratrol to support healthy inflammatory response, neuroprotection, and immune system balance through the body's own endogenous fatty acid signaling pathways.
Key Benefits of Palmitoylethanolamide (PEA) and Resveratrol Ingredients
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Palmitoylethanolamide (PEA, 350mg per capsule)
- Supports healthy inflammatory response as a bio-identical fatty acid amide naturally synthesized by the body's own tissues, promoting neuroprotection, immune modulation, and homeostasis regulation through endocannabinoid-adjacent signaling pathways
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Resveratrol (50mg, from Polygonum Cuspidatum Root Extract)
- Supports Nrf2 pathway activation and promotes antioxidant defense, sirtuin signaling, and healthy inflammatory response, complementing PEA's anti-inflammatory activity through a distinct molecular mechanism
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Glial Cell and Mast Cell Support
- PEA is found naturally in glia, neurons, mast cells, and white blood cells, and supplementation supports healthy regulation of these non-neuronal immune cells that play a central role in neurological inflammatory signaling
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Neuroprotective Support
- PEA supports healthy neuronal function at the cellular level and promotes neuroprotection through its activity on PPAR-alpha receptors and its modulation of glial cell inflammatory activity
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Healthy Inflammatory Response Support
- PEA supports the body's natural resolution of inflammatory signaling and promotes a balanced immune response without suppressing normal immune function
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Muscle Recovery Support
- PEA supports healthy recovery from physical exertion and promotes comfort in muscle tissue through its endogenous inflammatory modulation activity
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Immune System Balance
- PEA supports healthy mast cell regulation and promotes balanced immune responses in tissues throughout the body, including the nervous system and peripheral immune compartments
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Homeostasis Regulation
- As a bio-identical compound naturally produced by the body, PEA supports the restoration of physiological balance in tissues experiencing inflammatory stress
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Backed by Extensive Research
- PEA has been the subject of more than 300 published medical studies examining its role in inflammatory response, neuroprotection, and immune modulation
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Plant-Based Capsule Delivery
- Hypromellose capsule supports a clean, gelatin-free delivery system suitable for a broad range of dietary preferences
PEA Soothe Support is built around Palmitoylethanolamide, a naturally occurring fatty acid amide that the body produces in response to tissue stress and inflammatory signaling. Unlike many anti-inflammatory compounds that work by blocking specific enzymes or receptors, PEA supports the body's own endogenous regulatory mechanisms, promoting a more physiologically integrated approach to inflammatory balance. The addition of Resveratrol from Polygonum Cuspidatum provides complementary antioxidant and Nrf2 pathway support, addressing the oxidative component of inflammatory processes that PEA alone does not directly target, making this enhanced formula a more comprehensive option than single-ingredient PEA products.
Dietary and Quality Standards
- Non-GMO
- Gluten-Free
- Soy-Free
- Dairy-Free
- No artificial colors, flavors, or preservatives
- Bio-identical PEA (350mg per capsule, enhanced dose)
- Plant-based hypromellose capsule
- Manufactured in a GMP-certified facility
- Professional-grade formula
Frequently Asked Questions
Who is PEA Soothe Support designed for?
PEA Soothe Support is formulated for adults seeking support for healthy inflammatory response, neuroprotection, and immune system balance. It is commonly used in integrative and functional medicine protocols addressing neurological wellness, physical recovery, and conditions associated with elevated inflammatory signaling. Children should consult with a healthcare provider before use.
How should PEA Soothe Support be taken?
The recommended use is 1 capsule twice daily with food, or as directed by a qualified healthcare professional. For individuals beginning a PEA regimen, some practitioners recommend an initial loading phase of 4 capsules daily for two to three weeks before reducing to the standard twice-daily dose. This approach should be guided by a healthcare practitioner based on individual needs.
What is Palmitoylethanolamide (PEA) and how does it work?
Palmitoylethanolamide is a bio-identical fatty acid amide that is naturally synthesized by the body's own tissues in response to inflammatory stress. It is found throughout the body in glia, neurons, mast cells, white blood cells, and other tissues. PEA supports healthy inflammatory response primarily through PPAR-alpha receptor activation and modulation of non-neuronal immune cells such as mast cells and microglia, promoting a balanced and physiologically integrated approach to inflammatory regulation.
Resveratrol from Polygonum Cuspidatum Root Extract supports healthy inflammatory response and antioxidant defense through Nrf2 pathway activation and sirtuin signaling, mechanisms that are distinct from PEA's PPAR-alpha activity. By combining PEA and Resveratrol, this formula addresses both the endogenous inflammatory signaling pathway and the oxidative component of inflammatory processes, providing more comprehensive support than PEA alone.
What is the recommended loading phase for PEA?
Some healthcare practitioners recommend an initial loading phase of 4 capsules daily for two to three weeks when beginning a PEA regimen, before reducing to the standard twice-daily maintenance dose. This approach is based on clinical observations that higher initial doses may support faster establishment of therapeutic PEA tissue levels. The loading phase should be discussed with and guided by a qualified healthcare practitioner.
How long does it typically take to notice the effects of PEA supplementation?
Individual responses to PEA supplementation vary based on health status, baseline inflammatory burden, and dosing protocol. Some individuals notice effects within the first few weeks, while others may require a longer period of consistent use. PEA is generally considered appropriate for ongoing use as part of a comprehensive wellness protocol, and results should be evaluated in consultation with a healthcare practitioner.
Does this product contain any common allergens?
PEA Soothe Support is formulated to be free of gluten, soy, and dairy. It contains no artificial colors, flavors, or preservatives and uses a plant-based hypromellose capsule. Individuals with specific sensitivities should review the full ingredient list and consult their healthcare provider prior to use.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
