Methyl Folate Plus 90 Capsules by Neurobiologix is a targeted methylation support formula providing active folate in two bioavailable forms, 5-MTHF and folinic acid, alongside essential B vitamin cofactors designed to support neurological function, healthy homocysteine metabolism, and optimal methylation pathway activity.
Key Benefits of 5-MTHF, Folinic Acid, Riboflavin-5-Phosphate, and Niacinamide Ingredients
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5-MTHF (L-5-Methyltetrahydrofolate, as calcium salt, 9,770 mcg DFE combined)
- Supports active folate delivery directly to the methylation cycle without requiring enzymatic conversion, promoting neurological function, neurotransmitter synthesis, and healthy homocysteine metabolism
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Folinic Acid (as Folinic Acid Calcium Salt)
- Promotes conversion to tetrahydrofolate and supports folate availability in individuals with folate receptor autoantibodies or impaired folate transport across the blood-brain barrier
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Dual Folate Form Delivery (5-MTHF + Folinic Acid)
- Supports a more complete folate profile by addressing both the methylation cycle and the broader tetrahydrofolate pool, promoting comprehensive neurological and immune recovery
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Riboflavin-5-Phosphate (Vitamin B2, 30mg)
- Supports MTHFR enzyme activity as a critical cofactor and promotes healthy tissue repair, immune function, and nervous system integrity
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Niacinamide (as Niacin, 125mg)
- Supports mitochondrial energy production through NADH conversion and promotes healthy serotonin synthesis by sparing tryptophan for neurotransmitter production
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Blood-Brain Barrier Folate Support
- 5-MTHF is able to cross the blood-brain barrier and supports healthy acetylcholine synthesis, promoting cognitive function and neurological wellness
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MTHFR Polymorphism Support
- Provides folate in its pre-converted, biologically active form, supporting individuals with homozygous or heterozygous MTHFR variants who have reduced capacity to convert standard folic acid
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Folate Receptor Autoantibody (FOLR) Support
- Folinic acid supports an alternative folate transport pathway that may remain functional in individuals with folate receptor autoantibodies
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Cardiovascular Function Support
- Active folate supports healthy homocysteine metabolism, which is associated with maintaining healthy cardiovascular function
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Neurotransmitter Synthesis Support
- 5-MTHF supports the enzymatic reactions involved in the synthesis of serotonin, dopamine, and norepinephrine, promoting healthy mood and neurological balance
Methyl Folate Plus addresses a fundamental limitation of standard folic acid supplementation: the requirement for enzymatic conversion to the biologically active 5-MTHF form via the MTHFR enzyme. A significant portion of the population carries MTHFR gene variants that reduce this conversion efficiency, meaning standard folic acid supplements may not adequately support methylation or neurological function in these individuals. By providing both 5-MTHF and folinic acid alongside Riboflavin-5-Phosphate, a direct MTHFR enzyme cofactor, this formula supports the methylation pathway at multiple points simultaneously, making it particularly well-suited for use within comprehensive methylation protocols that include an activating B12 cofactor.
Dietary and Quality Standards
- Non-GMO
- Gluten-Free
- Wheat-Free
- Corn-Free
- Soy-Free
- Dairy-Free
- No artificial colors or preservatives
- Rice flour-based capsule fill (no magnesium stearate)
- Plant-based hypromellose capsule
- Manufactured in a GMP-certified facility
- Professional-grade formula
Frequently Asked Questions
Who is Methyl Folate Plus designed for?
Methyl Folate Plus is formulated for adults who require active folate support, particularly those with MTHFR gene variants, folate receptor autoantibodies, elevated homocysteine levels, or increased neurological folate demands. It is commonly used in methylation support protocols under the guidance of a qualified healthcare practitioner.
How should Methyl Folate Plus be taken?
The recommended use is 1 capsule twice daily, or as directed by a qualified healthcare professional. For individuals following a comprehensive methylation protocol, this product is designed to be used alongside a methylated B12 cofactor such as Methylation Complete or Methylation Pro Topical, as B12 is a required cofactor in the methylation cycle.
What is the difference between 5-MTHF and regular folic acid?
5-MTHF is the biologically active form of folate that the body can use directly in the methylation cycle without requiring enzymatic conversion. Regular folic acid must be converted through multiple enzymatic steps, including the MTHFR enzyme, before it becomes metabolically active. Individuals with MTHFR variants or other conversion impairments may not efficiently complete this process, making active 5-MTHF a more reliable option for supporting methylation.
5-MTHF and folinic acid support folate availability through complementary pathways. 5-MTHF directly enters the methylation cycle and crosses the blood-brain barrier, while folinic acid supports the broader tetrahydrofolate pool and may remain accessible in individuals with folate receptor autoantibodies who have impaired transport of 5-MTHF into the central nervous system. Together they provide more comprehensive folate support than either form alone.
Riboflavin-5-Phosphate is the active, phosphorylated form of Vitamin B2 and serves as a direct cofactor for the MTHFR enzyme. Without adequate riboflavin, MTHFR enzyme activity is reduced even in individuals without genetic variants. Including Riboflavin-5-Phosphate supports optimal MTHFR function and promotes the overall efficiency of the methylation pathway.
Niacinamide supports mitochondrial energy production through its conversion to NADH, a coenzyme essential for cellular metabolism. It also spares tryptophan from being used for niacin synthesis, making more tryptophan available for serotonin production. This is particularly relevant in neurological support protocols where neurotransmitter balance is a clinical consideration.
Does this product contain any common allergens?
Methyl Folate Plus is formulated to be free of wheat, gluten, corn, soy, and dairy. It contains no artificial colors or preservatives and uses a plant-based hypromellose capsule. Individuals with specific sensitivities should review the full ingredient list and consult their healthcare provider prior to use.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
