Codeage Liposomal L-Methylfolate 5-MTHF+ delivers active-form Vitamin B9 as L-Methylfolate (5-MTHF), Vitamin B12 as Methylcobalamin, Pyridoxal 5-Phosphate (B6), and Betaine Trimethylglycine (TMG) with Codeage's proprietary Helix liposomal delivery system to support methylation pathways, homocysteine metabolism, neurological function, and cardiovascular function.
Key Benefits of 26 Superfoods, Antioxidants and Adaptogens Ingredients
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L-Methylfolate as 5-MTHF Calcium Salt (800 mcg, Vitamin B9): The biologically active form of folate that bypasses the MTHFR enzymatic conversion step required to utilize folic acid. L-Methylfolate is directly usable by the body to support one-carbon metabolism, DNA synthesis, neurotransmitter production, and the maintenance of healthy homocysteine levels.
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Methylcobalamin (1,000 mcg, Vitamin B12): The active, methylated form of Vitamin B12 that supports neurological function, myelin sheath integrity, red blood cell formation, and the methylation cycle in conjunction with L-Methylfolate and TMG.
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Pyridoxal 5-Phosphate (Vitamin B6): The active coenzyme form of Vitamin B6 that supports amino acid metabolism, neurotransmitter synthesis, and the transsulfuration pathway involved in homocysteine metabolism.
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Betaine Trimethylglycine (TMG, 100 mg): A methyl donor that supports the remethylation of homocysteine to methionine through the BHMT pathway, complementing the folate and B12-dependent methylation cycle and promoting healthy homocysteine balance.
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Liposomal Delivery Complex (200 mg): Codeage's Helix liposomal system using phospholipids from non-GMO sunflower lecithin to promote the cellular absorption of the active B-vitamin compounds in this formula.
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Amino Acid Profile (from Liposomal Delivery Matrix): The liposomal phospholipid complex contributes a broad spectrum of amino acids including L-Glutamic Acid, L-Arginine, L-Leucine, L-Lysine, L-Valine, L-Phenylalanine, L-Isoleucine, L-Threonine, and additional essential and non-essential amino acids as part of the delivery matrix composition.
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Phosphatidylcholine from Non-GMO Sunflower Lecithin: The primary phospholipid in the liposomal carrier that supports neuronal membrane integrity, liver function, and cellular signaling as a standalone nutrient alongside its delivery function.
Why This Formula Matters
The methylation cycle is a fundamental biochemical process that supports DNA synthesis, neurotransmitter production, gene expression regulation, and the metabolism of homocysteine, an amino acid that accumulates when methylation is impaired. A significant portion of the population carries variants in the MTHFR gene that reduce the efficiency of converting folic acid into the active 5-MTHF form, making direct supplementation with L-Methylfolate relevant for supporting adequate folate status in these individuals. This formula pairs 5-MTHF with Methylcobalamin, Pyridoxal 5-Phosphate, and TMG to address the methylation cycle through multiple complementary pathways, and delivers these active-form nutrients via a liposomal phospholipid system to promote consistent cellular bioavailability.
Dietary and Quality Standards
- Vegan
- Non-GMO
- Gluten-Free
- Soy-Free
- Dairy-Free
- Methylcellulose (plant-based) capsule
- 1 capsule per serving, 60 servings per bottle (2-month supply)
- Manufactured in the USA in a cGMP-certified facility
- Global ingredients sourced for purity and potency
Frequently Asked Questions
What is L-Methylfolate (5-MTHF) and how does it differ from folic acid?
L-Methylfolate, also known as 5-MTHF, is the biologically active form of folate that the body can use directly without enzymatic conversion. Folic acid, the synthetic form found in most supplements and fortified foods, must be converted to 5-MTHF through a multi-step process that requires the MTHFR enzyme. Individuals with common MTHFR gene variants may have reduced capacity for this conversion, making direct supplementation with L-Methylfolate relevant for supporting adequate folate status and methylation function.
What is the methylation cycle and why does it matter?
The methylation cycle is a biochemical process in which methyl groups are transferred between molecules to support DNA synthesis, gene expression regulation, neurotransmitter production, and the metabolism of homocysteine. Adequate intake of active-form B-vitamins including L-Methylfolate, Methylcobalamin, and Pyridoxal 5-Phosphate supports the normal function of this cycle. TMG provides an additional methyl donor pathway that complements the folate and B12-dependent route.
Why are the methylated forms of B6, B9, and B12 used in this formula?
The methylated and active coenzyme forms of these B-vitamins, specifically Pyridoxal 5-Phosphate (B6), L-Methylfolate (B9), and Methylcobalamin (B12), are the forms that the body uses directly in enzymatic reactions. Standard forms such as pyridoxine, folic acid, and cyanocobalamin require conversion steps that may be less efficient in some individuals. Using the active forms supports more direct utilization of these nutrients in the methylation cycle and related pathways.
What is TMG (Betaine Trimethylglycine) and why is it included?
Betaine Trimethylglycine (TMG) is a naturally occurring compound derived from beets that functions as a methyl donor in the body. It supports the remethylation of homocysteine to methionine through the BHMT (betaine-homocysteine methyltransferase) pathway, which operates independently of the folate and B12-dependent methylation cycle. Including TMG alongside L-Methylfolate and Methylcobalamin provides complementary support for healthy homocysteine metabolism through two distinct biochemical routes.
How should I take Codeage Liposomal L-Methylfolate 5-MTHF+?
Adults take 1 capsule daily with 8 ounces of water or a preferred beverage. The formula may be taken with or without food. Each bottle contains 60 capsules, providing a 2-month supply at the recommended daily serving. Pregnant or nursing mothers and individuals with known medical conditions should consult a physician before use.
Is this product suitable for vegans and those with common dietary restrictions?
Yes. Codeage Liposomal L-Methylfolate 5-MTHF+ is vegan, non-GMO, gluten-free, soy-free, and dairy-free. The capsule is made from methylcellulose, a plant-based alternative to gelatin. It is manufactured in the USA in a cGMP-certified facility using globally sourced ingredients.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
