L-Methylfolate 15 mg with Cofactors | Allergy Research Group delivers a clinical-strength dose of the most bioavailable form of folate, paired with targeted cofactors to support methylation, neurotransmitter synthesis, and cardiovascular function.
Key Benefits of L-Methylfolate 15 mg with Cofactors
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Methylation Support
- Provides 15 mg of 5-MTHF, the active, ready-to-use form of folate that bypasses the MTHFR conversion step
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Neurotransmitter Synthesis
- Supports the production of serotonin, dopamine, and norepinephrine through the folate-dependent methylation cycle
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Cardiovascular Function
- Promotes healthy homocysteine metabolism, a key marker of cardiovascular and vascular health
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Cognitive and Mood Support
- Supports neurological function and emotional well-being through optimized one-carbon metabolism
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Cofactor Synergy
- Formulated with complementary B-vitamins to enhance folate utilization and methylation efficiency
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Bioavailable Delivery
- Supplies folate in the 6(S)-5-methyltetrahydrofolate form, the predominant circulating form in human plasma
Many individuals carry MTHFR gene variants that impair the conversion of dietary folate into its active form, making supplementation with L-methylfolate directly relevant to methylation capacity. This formula pairs the active folate with cofactors that work synergistically within the methylation cycle, supporting more complete utilization at the cellular level. The result is a targeted, clinically relevant approach to folate repletion for those with elevated needs.
Dietary & Quality Standards
- Non-GMO
- Gluten-Free
- Free of common allergens
- Manufactured under GMP-compliant conditions
- Third-party tested for potency and purity
- No artificial colors, flavors, or preservatives
Frequently Asked Questions
What is L-methylfolate and how does it differ from folic acid?
L-methylfolate is the biologically active form of folate that the body can use directly, without requiring enzymatic conversion. Folic acid, the synthetic form found in most fortified foods, must be converted through multiple steps - a process that is significantly impaired in individuals with MTHFR gene variants.
Who may benefit from a high-dose L-methylfolate supplement?
Individuals with MTHFR polymorphisms, those with elevated homocysteine levels, and people seeking targeted support for methylation, mood, or neurological function may benefit from supplementing with active folate at clinical doses. Consult a qualified healthcare provider before starting any new supplement regimen.
The cofactors in this formula are B-vitamins that participate directly in the methylation cycle alongside folate. These nutrients work together to support the conversion of homocysteine to methionine and the downstream production of SAMe, the body's primary methyl donor.
How should this product be taken?
Follow the dosage instructions on the product label or as directed by your healthcare practitioner. Because this is a high-potency formula, professional guidance is recommended, particularly for individuals new to methylfolate supplementation.
Is this product suitable for vegetarians or vegans?
Please refer to the product label for complete ingredient and capsule composition details. Allergy Research Group products are formulated with quality and dietary compatibility in mind; contact the manufacturer or your distributor for specific dietary suitability confirmation.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Suggested Use:
Use as directed by a healthcare professional
Supplement Facts:
Serving Size: 1 Capsule
Servings Per Container: 30
Amount Per Serving:
Vitamin B6 (as 17 mg Pyridoxal 5' Phosphate) ... 15 mg
Folate (15 mg from L-5-Methylfolate, calcium salt) ... 25 mg DFE
Vitamin B12 (as Methylcobalamin) ... 1000 mcg
Magnesium (as Amino Acid Chelate) ... 125 mg
Other Ingredients:
vegetarian cellulose capsule, L-leucine
Allergens:
According to information provided by our suppliers, these capsules are free of the nine major allergens as identified by the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA): Wheat (gluten), eggs, milk, soybeans, shellfish, fish, peanuts, tree nuts, and sesame.
Warnings:
Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement.
