D3 5000 + K1/K2 by Neurobiologix is a professional-grade fat-soluble vitamin formula designed to support healthy calcium metabolism, promote normal bone and vascular tissue integrity, and maintain healthy immune function through the synergistic combination of high-potency Vitamin D3 with both forms of Vitamin K. This 60-capsule formula delivers 5,000 IU of Vitamin D3 alongside Vitamin K1 and Vitamin K2 as MK-7, addressing the calcium routing and tissue protection functions that Vitamin D3 alone cannot provide.
Key Benefits of Vitamin D3, K1, K2 MK-7, and Synergistic Cofactors
- Vitamin D3 (as Cholecalciferol, 5,000 IU): Supports healthy calcium and phosphorus absorption in the small intestine, promotes normal osteoblast activity for bone matrix mineralization, and maintains healthy immune modulation through Vitamin D receptor activity in immune cells throughout the body.
- Vitamin K2 (as Menaquinone-7, MK-7): The most bioavailable and longest-acting form of Vitamin K2, supporting healthy osteocalcin carboxylation for normal calcium deposition into bone matrix and activating matrix Gla-protein (MGP) to maintain healthy calcium clearance from soft tissues and vascular walls.
- Vitamin K1 (as Phylloquinone): Supports healthy carboxylation of coagulation factors II, VII, IX, and X, promoting normal clotting factor activity and complementing K2's role in bone and vascular tissue calcium regulation.
- Calcium Routing and Bone Matrix Support: The combination of D3 and K2 MK-7 addresses both the absorption and the routing of calcium, with D3 promoting healthy intestinal calcium uptake and K2 activating the proteins that direct calcium into bone matrix rather than soft tissues.
- Vascular Tissue Integrity: K2 MK-7 activates matrix Gla-protein (MGP), the most potent known inhibitor of vascular calcification, supporting healthy calcium clearance from arterial walls and maintaining healthy vascular flexibility and cardiovascular tissue integrity.
- Immune System Modulation: Vitamin D3 supports healthy T-cell and B-cell differentiation, promotes normal innate and adaptive immune responses, and maintains healthy immune tolerance through Vitamin D receptor signaling in immune tissue.
- Bone Mineral Density Maintenance: The D3 and K2 combination supports healthy osteocalcin activity and promotes normal bone remodeling balance between osteoblast formation and osteoclast resorption, maintaining healthy bone mineral density over time.
- Muscle Function and Neuromuscular Health: Vitamin D3 supports healthy muscle fiber function, promotes normal neuromuscular coordination, and maintains healthy physical performance and balance in adults with adequate vitamin D status.
- Mood and Cognitive Function Support: Vitamin D receptors are expressed throughout the brain, and adequate D3 status supports healthy serotonin synthesis, promotes normal mood regulation, and maintains healthy cognitive function and neurological tissue integrity.
- Thyroid and Metabolic Function: Vitamin D3 supports healthy thyroid hormone receptor sensitivity and promotes normal metabolic rate and energy utilization in conjunction with adequate thyroid function.
- Parathyroid Hormone (PTH) Regulation: Adequate Vitamin D3 status supports healthy PTH suppression, promoting normal calcium homeostasis and maintaining healthy bone resorption balance by reducing excessive PTH-driven osteoclast activity.
- Magnesium Cofactor Dependency (note for practitioners): Vitamin D3 requires magnesium for its conversion to the active 25-hydroxyvitamin D form in the liver and 1,25-dihydroxyvitamin D in the kidney. Practitioners may consider assessing magnesium status alongside Vitamin D supplementation for optimal clinical outcomes.
D3 5000 + K1/K2 addresses a critical gap in standard Vitamin D supplementation by including both K1 and K2 MK-7 alongside a clinically relevant 5,000 IU dose of D3, recognizing that high-dose Vitamin D3 supplementation increases the body's demand for Vitamin K-dependent protein activation and that supplementing D3 without adequate K2 may not fully support healthy calcium routing to bone. The 5,000 IU dose is appropriate for individuals with confirmed or suspected Vitamin D insufficiency, as lower doses of 400 to 1,000 IU are often insufficient to raise and maintain serum 25-hydroxyvitamin D levels in the optimal range in adults with limited sun exposure, darker skin tones, or impaired D3 absorption. By combining D3 with MK-7, the longest-acting form of K2, this formula provides sustained K2 activity over a 72-hour period from a single daily capsule, supporting consistent osteocalcin and MGP activation throughout the dosing interval.
Dietary & Quality Standards
- Free from wheat, gluten, soy, milk, eggs, fish, crustacean shellfish, tree nuts, and peanuts
- Vitamin D3 delivered as Cholecalciferol, the most bioavailable and clinically studied form
- Vitamin K2 delivered as MK-7 for superior bioavailability and 72-hour duration of action
- Both K1 and K2 included for comprehensive Vitamin K-dependent protein activation
- Free from artificial colors, flavors, and preservatives
- Manufactured by Neurobiologix under professional-grade quality standards
- Practitioner-formulated for clinical and integrative wellness use
Frequently Asked Questions
What is D3 5000 + K1/K2 used for?
D3 5000 + K1/K2 is a fat-soluble vitamin formula designed to support healthy calcium metabolism, promote normal bone and vascular tissue integrity, and maintain healthy immune function. It is intended for adults seeking a high-potency Vitamin D3 supplement with comprehensive Vitamin K support for daily bone, immune, and cardiovascular tissue health.
How do I take D3 5000 + K1/K2?
The recommended use is as directed by a qualified healthcare practitioner based on individual Vitamin D status assessed by serum 25-hydroxyvitamin D testing. Because D3, K1, and K2 are fat-soluble vitamins, this product is best taken with a meal containing dietary fat to support optimal absorption.
Why is 5,000 IU of Vitamin D3 included rather than a lower dose?
Many adults, particularly those with limited sun exposure, darker skin tones, obesity, or malabsorption conditions, require higher supplemental doses to achieve and maintain serum 25-hydroxyvitamin D levels in the clinically optimal range of 40 to 60 ng/mL. The 5,000 IU dose is commonly used in clinical practice for individuals with confirmed insufficiency, though the appropriate dose for any individual should be determined by a healthcare provider based on baseline serum levels and follow-up testing.
K1 and K2 serve distinct physiological roles. K1 is primarily used by the liver for coagulation factor carboxylation, while K2 is preferentially distributed to bone and vascular tissues where it activates osteocalcin and matrix Gla-protein. Including both forms ensures comprehensive Vitamin K-dependent protein activation across hepatic, skeletal, and vascular tissues, rather than targeting only one physiological pathway.
Is D3 5000 + K1/K2 safe to take with anticoagulant medications such as warfarin?
Vitamin K1 and K2 directly affect the activity of Vitamin K-dependent coagulation factors and can interact with warfarin and other anticoagulant medications. Individuals taking warfarin or other anticoagulants should not use this product without first consulting their healthcare provider and having their INR monitored regularly. Do not adjust or discontinue anticoagulant medications without medical supervision.
Should I have my Vitamin D levels tested before taking this product?
Testing serum 25-hydroxyvitamin D levels before and after supplementation is recommended when using higher-dose Vitamin D3 products such as this formula. Baseline testing helps determine whether supplementation is appropriate and at what dose, and follow-up testing at 3 to 6 months confirms whether the target serum level has been achieved. Consult your healthcare provider for appropriate testing and dosing guidance.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
