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The formula in this supplement is a natural and safe method to regulating the production of histamine and other modulators of the immune system, allowing it to moderate the response of the immune system at a cellular level. The addition of quercetin prevents the creation of enzymes required for the degranulation and release of histamine. The bromelain stops the production of fibrin and kinins to bring about a healthy response from the immune system. Turmeric helps the body manage and sustain the healthy release of histamine as well as keeps the cell function of the immune system working properly. Ginger is a moderator of thromboxane and leukotriene synthesis thereby keeping the mechanisms of tissue and cellular support in working order.