E-400 (Mixed Tocopherols) by NOW delivers 400 IU of natural, unesterified Vitamin E in its complete tocopherol form — providing full-spectrum fat-soluble antioxidant support that mirrors the way Vitamin E occurs naturally in food sources.
Key Benefits of Mixed Tocopherols (Vitamin E)
- Full-Spectrum Antioxidant Protection — Unlike single-form Vitamin E supplements, this formula provides all four natural tocopherol fractions — d-alpha, d-beta, d-delta, and d-gamma — delivering broad-spectrum antioxidant activity across multiple cellular environments.
- Cellular Membrane Defense — As a fat-soluble antioxidant, Vitamin E integrates directly into cell membranes, where it supports protection of lipid structures from free radical-induced oxidative stress.
- Immune Function Support — Vitamin E plays a recognized role in maintaining normal immune cell function, supporting the body's natural defense mechanisms at the cellular level.
- Cardiovascular Function Support — Vitamin E contributes to the maintenance of healthy vascular function by supporting the integrity of lipid-rich cell membranes within the cardiovascular system.
- Skin Health Maintenance — Vitamin E's antioxidant activity supports the structural integrity of skin cells, contributing to the maintenance of healthy skin appearance and resilience.
- Unesterified Natural Form — This formula uses unesterified d-alpha Tocopherol, the natural form of Vitamin E, which is more bioavailable than synthetic dl-alpha Tocopherol (all-rac-alpha-tocopherol) commonly found in lower-cost formulations.
Most single-ingredient Vitamin E supplements provide only d-alpha Tocopherol in isolation — but in nature, Vitamin E exists as a family of eight related compounds, with the four tocopherol fractions (alpha, beta, delta, gamma) each contributing distinct antioxidant activity in different tissue environments. Research suggests that gamma- and delta-tocopherols, in particular, offer complementary antioxidant mechanisms not fully replicated by alpha-tocopherol alone. By delivering all four tocopherol fractions in a single softgel, this formula more closely reflects the complete Vitamin E complex found in whole food sources, supporting a more physiologically aligned approach to fat-soluble antioxidant supplementation.
Dietary & Quality Standards
- Gluten-Free — Contains no wheat or gluten
- Free of Common Allergens — No egg, corn, shellfish, yeast, starch, or sugar
- No Preservatives — Clean-label formulation with no artificial additives
- Natural Tocopherol Form — Uses unesterified d-alpha Tocopherol (natural form), not synthetic dl-alpha
- cGMP Manufactured — Produced by NOW Foods under current Good Manufacturing Practices
- Non-Heat Sensitive — Standard storage conditions apply; no refrigeration required
⚠️ Allergen disclosure: This product contains a soy derivative (from the mixed tocopherol source)
Frequently Asked Questions
What is the difference between mixed tocopherols and standard Vitamin E?
Standard Vitamin E supplements typically contain only d-alpha Tocopherol, the most studied tocopherol fraction. Mixed Tocopherol formulas additionally include d-beta, d-delta, and d-gamma Tocopherol — providing a broader spectrum of antioxidant activity that more closely mirrors the complete Vitamin E complex found in dietary sources such as nuts, seeds, and vegetable oils.
What does "unesterified" mean and why does it matter?
Unesterified Vitamin E (d-alpha Tocopherol) refers to the free, biologically active form of the vitamin, as opposed to esterified forms (such as d-alpha Tocopheryl Acetate or Succinate). The unesterified form is immediately bioavailable without requiring enzymatic conversion, making it the preferred form for individuals seeking direct antioxidant activity.
Is natural Vitamin E more effective than synthetic Vitamin E?
Natural Vitamin E (d-alpha Tocopherol) has greater biological activity than synthetic Vitamin E (dl-alpha Tocopherol). The natural form is recognized and retained by the body more efficiently, with research indicating approximately twice the bioavailability of the synthetic form at equivalent IU doses.
Does this product contain soy?
Yes — this formula contains a soy derivative, which is the natural source of the mixed tocopherol complex. Individuals with soy allergies or sensitivities should consult a healthcare provider before use.
Is this product suitable for vegans?
No — E-400 uses a gelatin-based softgel capsule, which is derived from bovine sources. This product is not suitable for vegans or strict vegetarians. Individuals seeking a vegan Vitamin E option should look for formulations using plant-derived capsules.
How should E-400 Mixed Tocopherols be taken?
The recommended serving is 1 softgel daily, preferably taken with a meal containing dietary fat. As a fat-soluble vitamin, Vitamin E absorption is significantly enhanced when consumed alongside fat-containing foods.
How should this product be stored?
Store in a cool, dry place away from direct sunlight and moisture. No refrigeration is required. Keep out of reach of children.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Suggested Use: Take one softgel daily, with a meal, or as directed by your health care professional.
Supplement Facts:
Serving Size: 1 softgel
Servings Per Container: 100/250
Amount Per Serving - Daily Value (%):
Vitamin E (as d-alpha Tocopherol) 268 mg - 1,787%
Other Ingredients:
Softgel Capsule [bovine gelatin (BSE-free), glycerin, water], Organic Extra Virgin Olive Oil and Mixed Tocopherols (d-beta, d-delta, d-gamma).
*Contains: Soy (Vitamin E from non-GMO soy).
*Not manufactured with yeast, wheat, gluten, milk, egg, fish or shellfish ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
Warnings:
For adults only. Consult physician if pregnant/nursing, taking medication, or have a medical condition. Keep out of reach of children.
Storage:
Store in a cool, dry place after opening.
**These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
