{"product_id":"osteo-mk4-k2-d3-60-capsules-nbi","title":"Osteo-MK4 K2+D3 60 Capsules by NBI","description":"\u003cp class=\"_p_13sb5_107\"\u003e\u003cstrong\u003e\u003cspan\u003eOsteo-MK4 K2+D3\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e by NBI is a professional-grade bone and cardiovascular support formula designed to support healthy bone mineral density, promote normal calcium utilization, and maintain healthy vascular tissue integrity through the targeted combination of Vitamin K2 as MK-4, Vitamin D3, and complementary bone health cofactors. This 60-capsule formula is specifically formulated for individuals who require or prefer the MK-4 form of Vitamin K2, which has a distinct tissue distribution profile and has been studied extensively in clinical bone density research.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 id=\"key-benefits-of-vitamin-k2-mk-4-vitamin-d3-and-bone-supporting-cofactors\" class=\"_h2_13sb5_72\"\u003e\u003cspan\u003eKey Benefits of Vitamin K2 MK-4, Vitamin D3, and Bone-Supporting Cofactors\u003c\/span\u003e\u003c\/h2\u003e\n\u003cul class=\"_ul_13sb5_144\"\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eVitamin K2 (as Menaquinone-4, MK-4):\u003c\/strong\u003e The form of Vitamin K2 most extensively studied in clinical bone density research, supporting healthy osteocalcin carboxylation for normal calcium deposition into bone matrix and activating matrix Gla-protein (MGP) to maintain healthy calcium clearance from soft tissues and vascular walls.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eVitamin D3 (as Cholecalciferol):\u003c\/strong\u003e Supports healthy intestinal calcium absorption, promotes normal osteoblast activity, and maintains healthy immune modulation in bone and musculoskeletal tissue. Works synergistically with K2 to support healthy calcium routing from the gut to bone.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eCalcium (as Calcium Citrate):\u003c\/strong\u003e A highly bioavailable organic calcium form that supports healthy bone mineral density and promotes normal calcium availability for bone matrix deposition, muscle function, and nerve conduction.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eMagnesium (as Magnesium Glycinate):\u003c\/strong\u003e Supports healthy hydroxyapatite crystal formation in bone matrix, promotes normal osteoblast and osteoclast activity, and maintains healthy muscle and nerve function essential for skeletal support.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eVitamin K1 (as Phylloquinone):\u003c\/strong\u003e Supports healthy carboxylation of bone Gla-proteins and promotes normal coagulation factor activity, complementing MK-4's role in bone matrix mineralization.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eZinc (as Zinc Bisglycinate):\u003c\/strong\u003e Supports healthy alkaline phosphatase activity in bone tissue, promotes normal collagen synthesis, and maintains healthy osteoblast function and bone matrix formation.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eBoron (as Boron Glycinate):\u003c\/strong\u003e Supports healthy estrogen and testosterone metabolism relevant to bone density maintenance, promotes normal magnesium and calcium utilization, and maintains healthy bone mineral density in postmenopausal and aging populations.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eSilicon (as Silicon Dioxide):\u003c\/strong\u003e Supports healthy collagen cross-linking in bone matrix and promotes normal bone mineralization and structural integrity in the early stages of bone formation.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eManganese (as Manganese Bisglycinate):\u003c\/strong\u003e An essential cofactor for glycosaminoglycan synthesis and superoxide dismutase activity, supporting healthy bone matrix formation and antioxidant defense in bone tissue.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eCopper (as Copper Bisglycinate):\u003c\/strong\u003e Supports healthy lysyl oxidase activity for collagen and elastin cross-linking, promoting normal connective tissue and bone matrix structural integrity.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eVitamin C (as Ascorbic Acid):\u003c\/strong\u003e An essential cofactor for collagen synthesis that supports healthy bone matrix formation and promotes antioxidant defense in bone and connective tissues.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eStrontium (as Strontium Citrate):\u003c\/strong\u003e Supports healthy bone formation activity and promotes normal osteoblast function, maintaining healthy bone mineral density as a structural trace mineral in bone tissue.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eIpriflavone:\u003c\/strong\u003e A synthetic isoflavone that supports healthy osteoblast activity and promotes normal bone mineral density maintenance, particularly in individuals with declining estrogen levels.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eVitamin B6 (as Pyridoxal-5-Phosphate):\u003c\/strong\u003e Supports healthy homocysteine metabolism, promoting normal collagen cross-linking in bone matrix and maintaining healthy bone structural integrity.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eFolate (as Methylfolate):\u003c\/strong\u003e Supports healthy methylation pathways that regulate homocysteine levels, promoting normal bone matrix collagen integrity and healthy osteoblast function.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eVitamin B12 (as Methylcobalamin):\u003c\/strong\u003e Supports healthy homocysteine metabolism and promotes normal osteoblast activity, maintaining healthy bone formation and normal nerve function in musculoskeletal tissue.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003ePhosphorus (as Calcium Phosphate):\u003c\/strong\u003e A primary structural mineral in hydroxyapatite, the mineral component of bone, supporting healthy bone density and promoting normal bone matrix mineralization.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e\u003cstrong\u003eVitamin A (as Beta-Carotene):\u003c\/strong\u003e Supports healthy osteoblast and osteoclast balance and promotes normal bone remodeling activity in conjunction with Vitamins D3 and K2.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 id=\"why-this-formula-matters\" class=\"_h2_13sb5_72\"\u003e\u003cspan\u003eWhy This Formula Matters\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"_p_13sb5_107\"\u003e\u003cspan\u003eOsteo-MK4 K2+D3 is specifically formulated around Vitamin K2 as MK-4, the form used in the majority of clinical bone density studies conducted in Japan and Europe, where it has been studied at pharmacological doses for its role in supporting healthy bone mineral density and normal osteocalcin activity. Unlike MK-7, which has a longer half-life and broader tissue distribution, MK-4 is rapidly taken up by specific tissues including bone, arterial walls, and reproductive organs, making it the preferred form for practitioners who follow the clinical research literature on K2 and bone health. By combining MK-4 with Vitamin D3, bioavailable calcium and magnesium, homocysteine-lowering B vitamins, and bone matrix structural cofactors, this formula provides a comprehensive and evidence-informed approach to bone density maintenance built around the most clinically studied form of Vitamin K2.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 id=\"dietary--quality-standards\" class=\"_h2_13sb5_72\"\u003e\u003cspan\u003eDietary \u0026amp; Quality Standards\u003c\/span\u003e\u003c\/h2\u003e\n\u003cul class=\"_ul_13sb5_144\"\u003e\n\u003cli\u003e\u003cspan\u003eFree from wheat, gluten, soy, milk, eggs, fish, crustacean shellfish, tree nuts, and peanuts\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eVitamin K2 delivered as MK-4, the form used in the majority of clinical bone density research\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eHighly bioavailable mineral forms including Calcium Citrate, Magnesium Glycinate, and chelated trace minerals\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eActive B vitamin forms (Methylcobalamin, Methylfolate, P5P) for enhanced bioavailability\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eManufactured by NBI under professional-grade quality standards\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ePractitioner-formulated for clinical and integrative wellness use\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 id=\"frequently-asked-questions\" class=\"_h2_13sb5_72\"\u003e\u003cspan\u003eFrequently Asked Questions\u003c\/span\u003e\u003c\/h2\u003e\n\u003ch3 id=\"what-is-osteo-mk4-k2d3-used-for\" class=\"_h3_13sb5_88\"\u003e\u003cspan\u003eWhat is Osteo-MK4 K2+D3 used for?\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"_p_13sb5_107\"\u003e\u003cspan\u003eOsteo-MK4 K2+D3 is a comprehensive bone health formula designed to support healthy bone mineral density, promote normal calcium utilization, and maintain healthy skeletal and vascular tissue integrity. It is intended for adults seeking evidence-informed nutritional support for long-term bone health maintenance, particularly those whose practitioners prefer the MK-4 form of Vitamin K2.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 id=\"what-is-the-difference-between-mk-4-and-mk-7-forms-of-vitamin-k2\" class=\"_h3_13sb5_88\"\u003e\u003cspan\u003eWhat is the difference between MK-4 and MK-7 forms of Vitamin K2?\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"_p_13sb5_107\"\u003e\u003cspan\u003eMK-4 and MK-7 are both forms of Vitamin K2 that activate osteocalcin and MGP, but they differ in their half-life, tissue distribution, and research base. MK-4 has a shorter half-life and is rapidly taken up by specific tissues including bone, arterial walls, and reproductive organs, and is the form used in the majority of clinical bone density studies. MK-7 has a longer half-life and broader tissue distribution, requiring only once-daily dosing. Both forms support healthy bone and vascular function through the same K2-dependent protein activation mechanisms.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 id=\"how-do-i-take-osteo-mk4-k2d3\" class=\"_h3_13sb5_88\"\u003e\u003cspan\u003eHow do I take Osteo-MK4 K2+D3?\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"_p_13sb5_107\"\u003e\u003cspan\u003eDosing should be directed by a qualified healthcare practitioner based on individual bone health status and nutritional needs. Because Vitamins D3, K1, K2, and A are fat-soluble, this product is best taken with meals containing dietary fat to support optimal absorption of these nutrients.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 id=\"why-does-this-formula-include-vitamin-k2-alongside-vitamin-d3\" class=\"_h3_13sb5_88\"\u003e\u003cspan\u003eWhy does this formula include Vitamin K2 alongside Vitamin D3?\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"_p_13sb5_107\"\u003e\u003cspan\u003eVitamin D3 promotes calcium absorption from the digestive tract, but without adequate Vitamin K2, that calcium may not be efficiently directed into bone tissue. K2 as MK-4 activates osteocalcin, which anchors calcium into bone matrix, and activates MGP, which supports healthy calcium clearance from soft tissues. This combination addresses both the absorption and the routing of calcium, which is why many integrative practitioners consider K2 an essential companion to D3 in bone support protocols.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 id=\"is-osteo-mk4-k2d3-safe-to-take-with-anticoagulant-medications-such-as-warfarin\" class=\"_h3_13sb5_88\"\u003e\u003cspan\u003eIs Osteo-MK4 K2+D3 safe to take with anticoagulant medications such as warfarin?\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"_p_13sb5_107\"\u003e\u003cspan\u003eVitamin K1 and K2 can interact with warfarin and other vitamin K-dependent anticoagulants by affecting clotting factor activity. Individuals taking warfarin or other anticoagulant medications should not use this product without first consulting their healthcare provider and having their INR monitored. Do not adjust or discontinue anticoagulant medications without medical supervision.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 id=\"is-osteo-mk4-k2d3-suitable-for-postmenopausal-women\" class=\"_h3_13sb5_88\"\u003e\u003cspan\u003eIs Osteo-MK4 K2+D3 suitable for postmenopausal women?\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"_p_13sb5_107\"\u003e\u003cspan\u003eThis formula includes Ipriflavone, a synthetic isoflavone that has been studied specifically for its role in supporting healthy bone mineral density in postmenopausal women, alongside MK-4, Vitamin D3, and bioavailable minerals. Consult your healthcare provider to determine whether this formula is appropriate for your individual health status, hormonal profile, and medication regimen.\u003c\/span\u003e\u003c\/p\u003e","brand":"NBI","offers":[{"title":"Default Title","offer_id":53618525372600,"sku":"NBI1008","price":65.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0217\/3199\/9816\/files\/Osteo-MK4_K2_D3_60_Capsules_by_NBI.png?v=1782226408","url":"https:\/\/blueskyvitamin.com\/products\/osteo-mk4-k2-d3-60-capsules-nbi","provider":"Blue Sky Vitamin","version":"1.0","type":"link"}